PCOS — polycystic ovarian syndrome — affects 10% of women. It’s caused by an imbalance in a woman’s reproductive hormones, and can cause everything from annoying acne, facial hair, hard to lose weight around your middle, and irregular cycles that can impact fertility.

So how do you treat it? Your endocrinologist might suggest a variety of therapies that are medical, but nutrition and diet also play a big role. According to PCOSnutrition.com and the PCOS Nutrition Center, a combined therapy with d-chiro-inositol (DCI) and myo-inositol (MI) improves the way the body uses insulin, reduces cravings, decreases androgens, and regulates menstrual cycles. It also improves ovarian function, regulates lipid levels, improves egg quality, and reduces the risk for gestational diabetes.

A 2016 study by Benelli and colleagues, published in the International Journal of Endocrinology, enrolled 46 women with PCOS. The women were randomly assigned to receive either a combination of DCI and MI, or placebo (folic acid) for 6 months. Dosing in the treatment group was 13.8 mg of DCI and 550 mg of MI.

The investigators looked specifically at pre-and post-treatment levels of the following:

  • Follicle-stimulating hormone (FSH)
  • Luteinizing hormone (LH)
  • 17-beta-estradiol
  • Sex hormone binding globulin
  • Androstenedione
  • Free testosterone
  • Dehydroepiandrosterone Sulphate
  • Homeostatic model assessment (HOMA) index
  • Fasting glucose
  • Insulin

They found statistically significant reductions in LH, free testosterone, fasting insulin, and HOMA index in the women treated with combined DCI and MI. These women also showed an increase in 17-beta-estradiol levels. The results reflect a positive effect of combined DCI and MI on endocrine and metabolic measures in women with PCOS.

How It Works

When we consume foods (like carbs), our bodies need to convert those foods into blood glucose, which can then be converted to energy. This process begins at the cellular level. When blood glucose levels rise, the cell membrane sends a signal to the nucleus to open the cell wall.

One way to imagine it is like the gatekeeper of a canal lock. When water levels inside and outside the lock are at the same level, the gatekeeper sends a signal to let the ship pass into, or out of, the lock. In women with PCOS, however, that signal is defective, causing a delay in the cell’s absorption of glucose. As a result, glucose accumulates in the blood and does not reach the cells as quickly or efficiently as it should. DCI and MI repair the signaling system so that the cell “lock gates” open in response to the presence of glucose.

Combination Treatment Is Better than Monotherapy 

A  2012 study by Nordio and Proietti, published in the European Review for Medical and Pharmacological and Sciences, examined a sample of 50 overweight women with PCOS. The women were divided into two groups, one receiving MI alone and the other receiving DCI and MI in combination over a 6-month period. Combined supplementation was shown to be more effective than MI alone in normalizing metabolic parameters.

So if you’re combating PCOS and are wanting to take a natural, healthy route to finding hormonal balance, Greens First Female ConceEVE Reproductive Support includes the proper combined doses of DCI and MI and can make a significant difference for you.